期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 26, 期 11, 页码 3436-3439出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfr521
关键词
biomineralization; nanobacteria; nanoparticles; vascular calcification
Biomineralization at pathological extraosseous sites (i.e. vasculature and soft tissues) is associated with increased morbidity and mortality. So-called 'nanobacteria' have been described as pathogenic agents causing many diseases including calcification. Initially, their appearance, and having a content consisting of nucleic acids plus proteins and properties of growing structures, suggested that they were living organisms. However, it could be demonstrated that the so-called nanobacteria were in fact mineralizing nanoparticles that contain mineral and non-mineral compounds, that these particles bind to charged molecules and that supersaturation enables in vitro growth of these nanoparticles. Recent data indicate that nanoparticles consisting of protein-mineral complexes can be seen both in vitro and in vivo as precursors of matrix calcification.
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