期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 25, 期 7, 页码 2376-2378出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfq224
关键词
deferasirox; Fanconi syndrome; iatrogenic disease; kidney failure
Deferasirox is the first oral iron chelator and, as such, is widely used for the treatment of chronic iron overload. However, recent data from large studies confirmed the renal toxicity of deferasirox. We report a case of Fanconi syndrome associated with acute renal failure in a patient receiving deferasirox. In particular, new insights regarding the pathophysiology of the renal disease due to this treatment are discussed. This case highlights the importance of a careful monitoring of kidney function, markers of proximal tubulopathy and ferritinaemia in patients receiving deferasirox.
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