期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 25, 期 2, 页码 638-641出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfp578
关键词
cinacalcet hydrochloride; intact PTH assay; N-PTH; whole PTH assay
资金
- Kyowa Hakko Kirin, Co. Ltd, Japan
Parathyroid hormone (PTH) levels measured with the intact PTH assays are generally higher than those measured with the whole PTH assay; however, rare exceptions to this rule have been reported in patients with severe hyperparathyroidism associated with N-PTH overproduction. We report a haemodialysis patient with severe secondary hyperparathyroidism, in whom abnormally higher whole PTH levels than intact PTH levels were normalized during cinacalcet therapy. Moreover, we observed a marked reduction in parathyroid gland vascularity during this treatment. Our findings suggested that increased sensitivity of the parathyroid calcium sensing receptor by calcimimetics may modulate the secretion or truncation of N-PTH or other PTH molecules that can be detected by the whole PTH assay but not by the intact PTH assays.
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