期刊
SOFT MATTER
卷 11, 期 3, 页码 456-465出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sm01760a
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资金
- National Natural Science Foundation of China [21303269, 21273287, 21033005]
- program for New Century Excellent Talents in University of Ministry of Education of China [NCET-10-0815]
- Natural Science Foundation for Distinguished Young Scholar of Shandong Province [JQ201008]
- Natural Science foundation of Shandong Province [ZR2013BQ029]
- Qingdao Science and Technology Project [13-1-4-235-jch]
- Fundamental Research Funds for the Central Universities
Recently, a unique dynamic magnetic field was developed to induce the rotational movement of superparamagnetic iron oxide nanoparticles. This technique has been applied to remotely control both cellular internalization and apoptosis. Therefore, a thorough understanding of how a lipid membrane responds to the introduction of rotating NPs is quite important to promote the applications of this technique in a variety of biomedical area. Here, we performed Dissipative Particle Dynamics (DPD) simulations to systematically investigate the interaction mechanism between lipid membranes and rotating NPs. Two kinds of membrane responses are observed. One is the promoted cell uptake and the other is the mechanical membrane rupture. The promoting effect of NP rotation on the cell uptake is ascribed to the enhanced membrane monolayer protrusion, which can wrap the NP from the top side. Meanwhile, the rotating NP exerts a shearing force on the membrane. Accordingly, the membrane undergoes a local distortion around the NP. If the shearing force exceeds a critical value, the local membrane distortion develops into a mechanical rupture. A number of factors, like NP size, NP shape, ligand density and rotation speed, are critical in both of the above membrane responses.
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