期刊
NEPHROLOGY
卷 17, 期 2, 页码 167-174出版社
WILEY
DOI: 10.1111/j.1440-1797.2011.01539.x
关键词
Chinese; cytokine genes; haemodialysis; hepatitis B; polymorphisms
资金
- Children's Miracle Network Awards
- Scientific Research Foundation of the State Human Resource Ministry for Selected Returned Overseas Chinese Scholars [2008-148]
- Key Lab of Jiangsu province [MMB09KF04]
- Scientific Research Program of the Health Department of Jiangsu Province [H200902, XK16200903]
- National Natural Science Foundation of China [H0511-81070588]
- International Cooperation Projects of Jiangsu province [BZ2010058]
- Blue Project 2010
Aim: To investigate the possible association of gene polymorphisms of tumour necrosis factor (TNF)-a (-238 and -308), interleukin (IL)-10 (-592 and -819) and 3' untranslated region (3'UTR) of the IL12B (-1188) and hepatitis B in Chinese Han haemodialysis (HD) patients. Methods: The genotyping of TNF-alpha -238 and -308, IL-10 -592 and -819 and 3'UTR of the IL12B were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Results: The TNF-alpha-238 A allele, the IL12B 3' UTR C/C, C/A genotypes were associated with decreased susceptibility to hepatitis B viral infection (P = 0.047, P = 0.003 and P = 0.001 respectively). The frequencies of IL-10-592 A/A genotype, IL-10-819 T/T genotype were lower in the HBV persistence group (P = 0.029 and P = 0.019) than those in the virus clearance group. Conclusions: TNF-alpha and IL12B 3'UTR gene polymorphismsmay be associated with HBV susceptibility and IL-10 gene polymorphisms may be related to the HBV persistence infection in Chinese Han HD patients.
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