期刊
SOFT MATTER
卷 11, 期 20, 页码 3971-3976出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sm00587f
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资金
- National Natural Science Foundation of China [51373124, 21007049]
- Wuhan Bureau of Science and Technology [2014070404010196]
- Program for New Century Excellent Talents in University [NECT-10-0618]
- Natural Science Foundation of Hubei Province [2011CDB268]
- Large-scale Instrument and Equipment Sharing Foundation of Wuhan University
Natural polymeric hydrogels with self-healing capability that can recover the functionalities and structures of gels after damage are extremely attractive due to their emerging applications in the biomedical field. Here we report a self-healable polymeric hydrogel by self-crosslinking two natural polymers acrylamide-modified chitin (AMC) containing amino groups and oxidized alginate containing dialdehyde groups. The generation of the self-crosslinked hydrogel relies on the dynamic covalent linkage through Schiff base between the polysaccharide chains. The self-healing capability of the crosslinked hydrogel depends on the molar ratio of AMC and oxidized alginate and the surrounding pH. Under certain circumstances, the damaged hydrogel shows a complete recovery and can be stretched to a favorable extent, which is seldom observed for polysaccharide self-healing hydrogel. Notably, we find that the self-healing ability can be stored by freeze-drying and activated by rehydration. In addition, we demonstrate that the hydrogel can be used as a soft template to guide the repair of inorganic materials like hydroxyapatite. We anticipate that this self-healable hydrogel consisting of biocompatible and biodegradable polysaccharides can be applied to various biomedical fields.
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