期刊
NEONATOLOGY
卷 97, 期 3, 页码 250-256出版社
KARGER
DOI: 10.1159/000253756
关键词
Bacteria; Bifidobacteria; Intestine; Lactobacilli
类别
资金
- Wyeth Nutrition
Background: Postnatal introduction of probiotics results in a low incidence of colonization, whereas maternal fecal and vaginal bacteria colonize the gastrointestinal tract (GIT) of vaginally delivered infants. Objective: We tested if probiotic bacteria, fed to three pregnant animal models, would colonize the GIT of offspring delivered vaginally. Methods: Probiotic strains of Lactobacillus acidophilus and Bifidobacterium lactis were fed to pregnant mice, rats, and sows for at least 7 days prior to vaginal delivery. Cultural approaches and genotyping were used to determine if the probiotic bacteria colonized the GIT after birth. Results: The probiotic bacteria were detected in the feces and vagina of maternal mice, rats, and sows after, but not before, administration. L. acidophilus was detected at postnatal day 14 in 22, 33, and 75% of the mice, rats, and pigs, respectively, and after weaning in 35% of the mice and 1 of 5 pigs. B. lactis was present at postnatal day 14 in 30 and 80% of the mice and pigs. Bacterial assemblages in the GIT of the colonized young differed from those in which the probiotics were not detected. Conclusions: Probiotic bacteria administered to mothers during late gestation are transferred to infants born vaginally and influence the assemblages of GIT bacteria. However, colonization of the neonatal GIT and persistence past weaning does not occur in all offspring and varies among probiotics and animal models. Copyright (C) 2009 S. Karger AG, Basel
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