期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 21, 期 4, 页码 423-U168出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2799
关键词
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资金
- Agency for Science, Technology and Research (A*STAR) of Singapore
- Genome Quebec, Genome Canada
- Canadian Institute of Health Research [CIHR MOP-115090]
- Singapore International Graduate Award from A*STAR
- German Academic Exchange Service, DAAD
Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.
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