期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 21, 期 4, 页码 308-316出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2792
关键词
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资金
- European Research Council [249997]
- Scientific Research-Chemical Sciences (NWO-CW) TOP [714.012.001]
- Cancer Genomics Centre (CGC. nl)
- European Research Council (ERC) [249997] Funding Source: European Research Council (ERC)
Ubiquitin and ubiquitin-like modifications are central to virtually all cellular signaling pathways. They occur primarily on lysine residues of target proteins and stimulate a large number of downstream signals. The diversity of these signals depends on the type, location and dynamics of the modification, but the role of the exact site of modification and the selectivity for specific lysines are poorly understood. Here we review the current literature on lysine specificity in these modifications, and we highlight the known signaling mechanisms and the open questions that pose future challenges to ubiquitin research.
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