期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 21, 期 1, 页码 20-25出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2738
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资金
- US National Institutes of Health [GM62267, GM80676]
- Cancer Research UK [17575] Funding Source: researchfish
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062267, R01GM080676] Funding Source: NIH RePORTER
In G1, two copies of the MCM2-7 helicase are recruited to each origin of replication. Whereas recruitment of the first MCM2-7 is likely to be analogous to the loading of sliding clamps around DNA, how the second MCM2-7 complex is recruited is highly contentious. Here, we argue that MCM2-7 loading involves specific modifications to the clamp-loading reaction and propose that the first and second MCM2-7 molecules are loaded via similar mechanisms.
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