期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 20, 期 10, 页码 1147-1155出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2669
关键词
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资金
- Spanish 'Ministerio de Educacion y Ciencia' [BFU2010-18692]
- European Commission [277899]
- Novo Nordisk Foundation
- Danish Cancer Society
- Danish Council for Strategic Research [12-110503]
- ICREA Funding Source: Custom
Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease. Mechanistically, they function within multiprotein complexes, called Polycomb repressive complexes (PRCs), which modify histones (and other proteins) and silence target genes. The dynamics of PRC1 and PRC2 components has been the focus of recent research. Here we discuss our current knowledge of the PRC complexes, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.
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