期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 20, 期 4, 页码 412-418出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2543
关键词
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资金
- Fondation pour la Recherche Medicale
- US National Institutes of Health [R01 GM058750]
- Biogerontology Research Foundation, UK
- Centre Nationale de la Recherche Scientifique (LEA-SkinChroma)
- Agence Nationale de la Recherche [ANR-09-BLAN-0266, ANR-09-BLAN-056]
- Institut National du Cancer
- European Community (EPIDICAN)
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0266] Funding Source: Agence Nationale de la Recherche (ANR)
To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses.
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