期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 20, 期 12, 页码 1346-1348出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2729
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资金
- NIGMS NIH HHS [R01 GM095515, R01 GM060980] Funding Source: Medline
Mediator of DNA-damage checkpoint 1 (MDC1) has a central role in repair of DNA double-strand breaks (DSBs) by both homologous recombination and nonhomologous end joining, and its function is regulated by post-translational phosphorylation, ubiquitylation and SUMOylation. In this issue, a new study by Watanabe et al. reveals that methylation of MDC1 is also critical for its function in DSB repair and specifically affects repair through BRCA1-dependent homologous recombination.
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