期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 19, 期 7, 页码 716-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2319
关键词
-
资金
- National Key Basic Research Program of China [2011CB910800]
- Natural Science Foundation of China [31130062, 31070643]
- Tsinghua University [09THZ02235]
The energy sensor AMP-activated protein kinase (AMPK) is a heterotrimeric complex that is allosterically activated by AMP binding to the gamma subunit. Cocrystal structures of the mammalian AMPK core reveal occlusion of nucleotide-binding site 3 of the gamma subunit in the presence of ATP. However, site 3 is occupied in the presence of AMP. Mutagenesis studies indicate that sites 3 and 4 are important for AMPK allosteric activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据