期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 19, 期 7, 页码 725-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2332
关键词
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资金
- State Key Laboratory of Microbial Technology, Shandong University
- Hi-Tech Research and Development Program of China [2006AA02A324]
- National Nature Science Foundation of China [31000330]
STING functions as both an adaptor protein signaling cytoplasmic double-stranded DNA and a direct immunosensor of cyclic diguanylate monophosphate (c-di-GMP). The crystal structures of the C-terminal domain of human STING (STING(CTD)) and its complex with c-di-GMP reveal how STING recognizes c-di-GMP. In response to c-di-GMP binding, two surface loops, which serve as a gate and latch of the cleft formed by the dimeric STING(CTD), undergo rearrangements to interact with the ligand.
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