期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 19, 期 7, 页码 722-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2331
关键词
-
资金
- US National Institute of Health [AI087741, AI073335]
STING (stimulator of interferon genes) is an innate immune sensor of cyclic dinucleotides that regulates the induction of type I interferons. STING's C-terminal domain forms a V-shaped dimer and binds a cyclic diguanylate monophosphate (c-di-GMP) at the dimer interface by both direct and solvent-mediated hydrogen bonds. Guanines of c-di-GMP stack against the phenolic rings of a conserved tyrosine, and mutations at the c-di-GMP binding surface reduce nucleotide binding and affect signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据