期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 19, 期 8, 页码 740-742出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2352
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资金
- NIGMS NIH HHS [P01 GM085354] Funding Source: Medline
The search for the holy replicator has been revitalized through ultradeep sequencing of small RNA-primed single-stranded DNA. Saturation sequencing provides an explanation for the lack of overlap in prior data sets, suggests that frequency of origin usage but not site selection is developmentally regulated, and uncovers a complex four-stranded DNA structure associated with most origins.
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