期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 18, 期 10, 页码 1175-1177出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2119
关键词
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资金
- Center for Game Science at the University of Washington, US Defense Advanced Research Projects Agency (DARPA) [N00173-08-1-G025]
- DARPA
- US National Science Foundation [IIS0811902]
- Czech Ministry of Education [1M0508, Z40550506]
- Howard Hughes Medical Institute
- Microsoft Corp.
- National Science Foundation [0906026]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0906026] Funding Source: National Science Foundation
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [0811902] Funding Source: National Science Foundation
Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.
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