期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 18, 期 3, 页码 392-394出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1982
关键词
-
资金
- US National Institutes of Health [EY012049, EY018891]
X-ray and magnetic resonance approaches, though central to studies of G protein-coupled receptor (GPCR)-mediated signaling, cannot address GPCR protein dynamics or plasticity. Here we show that solid-state H-2 NMR relaxation elucidates picosecond-to-nanosecond-timescale motions of the retinal ligand that influence larger-scale functional dynamics of rhodopsin in membranes. We propose a multiscale activation mechanism whereby retinal initiates collective helix fluctuations in the meta I-meta II equilibrium on the microsecond-to-millisecond timescale.
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