期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 17, 期 8, 页码 1027-1029出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1856
关键词
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资金
- US National Institutes of Health [GM070558]
- American Heart Association [0740058N]
MSL3 resides in the MSL (male-specific lethal) complex, which upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark. We discovered a DNA-dependent interaction of MSL3 chromodomain with the H4K20 monomethyl mark. The structure of a ternary complex shows that the DNA minor groove accommodates the histone H4 tail, and monomethyllysine inserts in a four-residue aromatic cage in MSL3. H4K16 acetylation antagonizes MSL3 binding, suggesting that MSL function is regulated by a combination of post-translational modifications.
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