期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 17, 期 1, 页码 5-10出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1762
关键词
-
资金
- US National Institutes of Health [GM071654-01]
- Peter Gruber Foundations
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM071654] Funding Source: NIH RePORTER
MicroRNAs (miRNAs) control essential gene regulatory pathways in plants and animals. Serving as guides in silencing complexes, miRNAs direct Argonaute proteins to specific target messenger RNAs to repress protein expression. The mature, 22-nucleotide (nt) miRNA is the product of multiple processing steps, and recent studies have uncovered factors that directly control the stability of the functional RNA form. Although alteration of miRNA levels has been linked to numerous disease states, the mechanisms responsible for stabilized or reduced miRNA expression have been largely elusive. The discovery of specific cis-acting modifications and trans-acting proteins that affect miRNA half-life reveals new elements that contribute to the homeostasis of these vital regulatory molecules.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据