期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 17, 期 10, 页码 1260-1262出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1904
关键词
-
资金
- Tobacco-Related Disease Research Program [17FT-0046]
- US National Institutes of Health [GM58015, CA92276]
- US Department of Defense [DAMD17-00-1-0187]
- Susan G. Komen Breast Cancer Foundation [BCTR0201259]
- University of California Davis Cancer Center
BRCA2 is a tumor suppressor that functions in homologous recombination, a key genomic integrity pathway. BRCA2 interacts with RAD51, the central protein of recombination, which forms filaments on single-stranded DNA (ssDNA) to perform homology search and DNA strand invasion. We report the purification of full-length human BRCA2 and show that it binds to similar to 6 RAD51 molecules and promotes RAD51 binding to ssDNA coated by replication protein A (RPA), in a manner that is stimulated by DSS1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据