期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 17, 期 10, 页码 1269-1271出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1890
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资金
- Centre National de la Recherche Scientifique
- Agence Nationale de Recherche
- Action Thematique et Incitative sur Programme (ATIP) of the Research Ministry
- Stowers Institute for Medical Research
- Fondation pour la Recherche Medicale
The exon junction complex (EJC), which is deposited onto mRNAs as a consequence of splicing, is involved in multiple post-transcriptional events in metazoa. Here, using Drosophila melanogaster cells, we show that only some introns trigger EJC-dependent nonsense-mediated mRNA decay and that EJC association with particular spliced junctions depends on RNA cis-acting sequences. This study provides the first evidence to our knowledge that EJC deposition is not constitutive but instead is a regulated process.
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