期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 17, 期 12, 页码 1492-1494出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1944
关键词
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资金
- Bill and Melinda Gates Foundation
- US Department of Energy, Office of Science, Office of Basic Energy Sciences [W-31-109-Eng-38]
The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.
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