期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 16, 期 9, 页码 904-907出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb0909-904
关键词
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Macrodomains function as binding modules for metabolites of NAD(+), including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair.
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