期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 16, 期 9, 页码 987-989出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1645
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资金
- American Lebanese Syrian Associated Charities (ALSAC)
- US National Institutes of Health (NIH) [P30CA021765]
- National Center for Research Resources at NIH [RR-15301]
- US Department of Energy, Office of Basic Energy Sciences [W-31-109-ENG-38]
- NATIONAL CANCER INSTITUTE [P30CA021765] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR015301] Funding Source: NIH RePORTER
The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein.
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