期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 16, 期 5, 页码 561-563出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1587
关键词
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资金
- Howard Hughes Medical Institute
- US National Institutes of Health [R01-GM56322, 1F32 GM06917902]
- Welch Foundation [I-1544]
The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.
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