期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 15, 期 7, 页码 675-683出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1455
关键词
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资金
- Intramural NIH HHS [Z01 HD001501-16] Funding Source: Medline
Diverse membrane fusion reactions in biology involve close contact between two lipid bilayers, followed by the local distortion of the individual bilayers and reformation into a single, merged membrane. We consider the structures and energies of the fusion intermediates identified in experimental and theoretical work on protein-free lipid bilayers. On the basis of this analysis, we then discuss the conserved fusion-through-hemifusion pathway of merger between biological membranes and propose that the entire progression, from the close juxtaposition of membrane bilayers to the expansion of a fusion pore, is controlled by protein-generated membrane stresses.
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