期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 15, 期 4, 页码 419-421出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1400
关键词
-
资金
- NCI NIH HHS [CA69472] Funding Source: Medline
The histone H3 lysine 4 demethylase RBP2 contains a DNA binding domain, the AT-rich interaction domain (ARID). We solved the structure of ARID by NMR, identified its DNA binding motif (CCGCCC) and characterized the binding contacts. Immunofluorescence and luciferase assays indicated that ARID is required for RBP2 demethylase activity in cells and that DNA recognition is essential to regulate transcription.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据