期刊
NATURE REVIEWS UROLOGY
卷 11, 期 12, 页码 688-701出版社
NATURE PORTFOLIO
DOI: 10.1038/nrurol.2014.301
关键词
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资金
- Prostate Cancer Canada [D2013-21]
- Canada Research Chair Program
- FAPESP (Sao Paulo Research Foundation) [12/24574-3]
- CAPES (Coordination for the Improvement of Higher Education Personnel)
- Swedish Research Council [K2012-52X-09495-25-3]
- BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy
- Stiftelsen Handlanden Hjalmar Svensson Foundation
- Magnus Bergvalls Foundation
- Associazione Italiana per la Ricerca sul Cancro (AIRC) IG [12890]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/24574-3] Funding Source: FAPESP
The knowledge gained from comprehensive profiling projects that aim to define the complex genomic alterations present within cancers will undoubtedly improve our ability to detect and treat those diseases, but the influence of these resources on our understanding of basic cancer biology is still to be demonstrated. Extracellular vesicles have gained considerable attention in past years, both as mediators of intercellular signalling and as potential sources for the discovery of novel cancer biomarkers. In general, research on extracellular vesicles investigates either the basic mechanism of vesicle formation and cargo incorporation, or the isolation of vesicles from available body fluids for biomarker discovery. A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets.
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