期刊
NATURE REVIEWS UROLOGY
卷 11, 期 1, 页码 18-31出版社
NATURE PORTFOLIO
DOI: 10.1038/nrurol.2013.266
关键词
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资金
- European Community [Health-F2-2009-223175-COGS]
- Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative (NIH ELLIPSE) [U19CA148537]
- CRUK (Cancer Research United Kingdom) [C5047/A10692 (PRACTICAL), C5047/A13232 (IMPACT)]
- Ronald and Rita McAulay Foundation
- Institute of Cancer Research Everyman Campaign
- Prostate Cancer UK
- National Institute for Health Research to the Biomedical Research Centre at The Institute of Cancer Research
- Royal Marsden Foundation NHS Trust
- Cancer Research UK [13232, 15007, 16563] Funding Source: researchfish
Worldwide, familial and epidemiological studies have generated considerable evidence of an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations have been implicated. Genome-wide association studies (GWAS) have also identified 76 susceptibility loci associated with prostate cancer risk, which occur commonly but are of low penetrance. However, these mutations interact multiplicatively, which can result in substantially increased risk. Currently, approximately 30% of the familial risk is due to such variants. Evaluating the functional aspects of these variants would contribute to our understanding of prostate cancer aetiology and would enable population risk stratification for screening. Furthermore, understanding the genetic risks of prostate cancer might inform predictions of treatment responses and toxicities, with the goal of personalized therapy. However, risk modelling and clinical translational research are needed before we can translate risk profiles generated from these variants into use in the clinical setting for targeted screening and treatment.
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