相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience
Ngayu Thairu et al.
ANGIOGENESIS (2011)
Hypoxia Induces Mitochondrial Mutagenesis and Dysfunction in Inflammatory Arthritis
Monika Biniecka et al.
ARTHRITIS AND RHEUMATISM (2011)
Tumor Necrosis Factor Blocking Therapy Alters Joint Inflammation and Hypoxia
Aisling Kennedy et al.
ARTHRITIS AND RHEUMATISM (2011)
Opposing roles for HIF-1α and HIF-2α in the regulation of angiogenesis by mononuclear phagocytes
Tim D. Eubank et al.
BLOOD (2011)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Eric V. Dang et al.
CELL (2011)
Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1α in Advanced Solid Tumors
Shivaani Kummar et al.
CLINICAL CANCER RESEARCH (2011)
CXCL12 gene expression is upregulated by hypoxia and growth arrest but not by inflammatory cytokines in rheumatoid synovial fibroblasts
Begona Santiago et al.
CYTOKINE (2011)
Treatment-Related Mortality With Bevacizumab in Cancer Patients A Meta-analysis
Vishal Ranpura et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression
Jonathan Jantsch et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2011)
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet et al.
NATURE (2011)
Mechanisms of Disease: Hypoxia and Inflammation.
Holger K. Eltzschig et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint
Monika Biniecka et al.
ANNALS OF THE RHEUMATIC DISEASES (2010)
Synovial tissue hypoxia and inflammation in vivo
C. T. Ng et al.
ANNALS OF THE RHEUMATIC DISEASES (2010)
Therapeutic Manipulation of the HIF Hydroxylases
Simon Nagel et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Angiogenesis and Blood Vessel Stability in Inflammatory Arthritis
Aisling Kennedy et al.
ARTHRITIS AND RHEUMATISM (2010)
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Andrew L. Doedens et al.
CANCER RESEARCH (2010)
Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
Christian Werno et al.
CARCINOGENESIS (2010)
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
Sergio Rey et al.
CARDIOVASCULAR RESEARCH (2010)
Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
Murtaza M. Tambuwala et al.
GASTROENTEROLOGY (2010)
Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity
Jing Xue et al.
GASTROENTEROLOGY (2010)
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
Norihiko Takeda et al.
GENES & DEVELOPMENT (2010)
The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1α prolyl hydroxylation
Sally A. Nicholas et al.
IMMUNOLOGY AND CELL BIOLOGY (2010)
New insights in synovial angiogenesis
Zoltan Szekanecz et al.
JOINT BONE SPINE (2010)
Prolyl Hydroxylase EGLN3 Regulates Skeletal Myoblast Differentiation through an NF-κB-dependent Pathway
Jian Fu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
Hongxia Z. Imtiyaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
Cesar A. Corzo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Clinical Significance of Serum Levels of Vascular Endothelial Growth Factor, Angiopoietin-1, and Angiopoietin-2 in Patients with Rheumatoid Arthritis
Daitaro Kurosaka et al.
JOURNAL OF RHEUMATOLOGY (2010)
Mechanism of Hypoxia-Induced NF-κB
Carolyn Culver et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Pleiotropic Effects of YC-1 Selectively Inhibit Pathological Retinal Neovascularization and Promote Physiological Revascularization in a Mouse Model of Oxygen-Induced Retinopathy
M. DeNiro et al.
MOLECULAR PHARMACOLOGY (2010)
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
G. L. Semenza
ONCOGENE (2010)
Human Inflammatory Synovial Fibroblasts Induce Enhanced Myeloid Cell Recruitment and Angiogenesis Through a Hypoxia-Inducible Transcription Factor 1α/Vascular Endothelial Growth Factor-Mediated Pathway in Immunodeficient Mice
Manuel J. del Rey et al.
ARTHRITIS AND RHEUMATISM (2009)
Inhibition of HIF-1α activity by BP-1 ameliorates adjuvant induced arthritis in rats
J. Shankar et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
Hsin-Yu Fang et al.
BLOOD (2009)
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Massimiliano Mazzone et al.
CELL (2009)
The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response
Sally A. Nicholas et al.
CELL RESEARCH (2009)
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
Gregg L. Semenza
PHYSIOLOGY (2009)
Immature Blood Vessels in Rheumatoid Synovium Are Selectively Depleted in Response to Anti-TNF Therapy
Elena Izquierdo et al.
PLOS ONE (2009)
Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation
Carol A. Hitchon et al.
RHEUMATOLOGY INTERNATIONAL (2009)
Angiogenesis and its targeting in rheumatoid arthritis
Zoltan Szekanecz et al.
VASCULAR PHARMACOLOGY (2009)
Hypoxia The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis
Barbara Muz et al.
ARTHRITIS RESEARCH & THERAPY (2009)
Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis
Mohammed A. Akhavani et al.
ARTHRITIS RESEARCH & THERAPY (2009)
Hypoxia Regulation of NF kappa B signalling during inflammation: the role of hydroxylases
Kathryn M. Oliver et al.
ARTHRITIS RESEARCH & THERAPY (2009)
Hypoxic synovial environment and expression of macrophage inflammatory protein 3α/CCL20 in juvenile idiopathic arthritis
Maria Carla Bosco et al.
ARTHRITIS AND RHEUMATISM (2008)
The Molecular Signature of Oxidative Metabolism and the Mode of Macrophage Activation Determine the Shift From Acute to Chronic Disease in Experimental Arthritis Critical Role of Interleukin-12p40
Nozomi Takahashi et al.
ARTHRITIS AND RHEUMATISM (2008)
Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: A nested, case-control study
Zurab Nadareishvili et al.
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH (2008)
Divergent effects of hypoxia on dendritic cell functions
Alessandra Mancino et al.
BLOOD (2008)
The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
Christina Warnecke et al.
EXPERIMENTAL CELL RESEARCH (2008)
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
Eoin P. Cummins et al.
GASTROENTEROLOGY (2008)
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
Andreas Robinson et al.
GASTROENTEROLOGY (2008)
Effects of hypoxia on transcription factor expression in human monocytes and macrophages
Laila Elbarghati et al.
IMMUNOBIOLOGY (2008)
Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts
H. Manabe et al.
INFLAMMATION RESEARCH (2008)
Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis
Branavan Sivakumar et al.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME (2008)
Hypoxia and hypoxia-inducible factor-1α modulate lipopolysaccharide-induced dendritic cell activation and function
Jonathan Jantsch et al.
JOURNAL OF IMMUNOLOGY (2008)
Expression of hypoxia-inducible angiogenic proteins (hypoxia-inducible factor-1α, vascular endothelial growth factor, and E26 transformation-specific-1) and plaque hemorrhage in human carotid atherosclerosis
Tetsuhiro Higashida et al.
JOURNAL OF NEUROSURGERY (2008)
Interdependent roles for hypoxia inducible factor and nuclear factor-kappa B in hypoxic inflammation
Cormac T. Taylor
JOURNAL OF PHYSIOLOGY-LONDON (2008)
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Jordi Rius et al.
NATURE (2008)
Bevacizumab Improves the Overall and Progression-Free Survival of Patients with Metastatic Colorectal Cancer Treated with 5-Fluorouracil-Based Regimens Irrespective of Baseline Risk
Fairooz Kabbinavar et al.
ONCOLOGY (2008)
Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner
Seiko Oda et al.
PLOS ONE (2008)
Role of hypoxia-inducible factor-1α in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes
J. K. Ahn et al.
RHEUMATOLOGY (2008)
Signalling, inflammation and arthritis -: NF-κB and its relevance to arthritis and inflammation
R. E. Simmonds et al.
RHEUMATOLOGY (2008)
Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia
Johannes Kuhlicke et al.
PLOS ONE (2007)
Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients
Yeon-Ah Lee et al.
CLINICAL RHEUMATOLOGY (2007)
ASB4 is a Hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism
James E. Ferguson et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
Frank A. Scappaticci et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
Cutting edge:: Essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis
Carole Peyssonnaux et al.
JOURNAL OF IMMUNOLOGY (2007)
Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1α
Margret C. M. Vissers et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2007)
Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site
Steve Bonello et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Under-expression of VHL and over-expression of HDAC-1, HIF-1 alpha, LL-37, and IAP-2 in affected skin biopsies of patients with psoriasis
Laura E. Tovar-Castillo et al.
INTERNATIONAL JOURNAL OF DERMATOLOGY (2007)
Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients
Sook Young Lee et al.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2006)
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
Eoin P. Cummins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
Matthew E. Cockman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB
Stilla Frede et al.
BIOCHEMICAL JOURNAL (2006)
Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection
Olga Aprelikova et al.
CANCER RESEARCH (2006)
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
A Sica et al.
EUROPEAN JOURNAL OF CANCER (2006)
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity:: Assessment of an oral agent that stimulates erythropoietin production
M Safran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
RR Raval et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
HIF-1α expression regulates the bactericidal capacity of phagocytes
C Peyssonnaux et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
TCR engagement increases hypoxia-inducible factor-1α protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
H Nakamura et al.
JOURNAL OF IMMUNOLOGY (2005)
Hypoxia-induced neutrophil survival is mediated by HIF-1α-dependent NF-κB activity
SR Walmsley et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
J Karhausen et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
The chemokine system in diverse forms of macrophage activation and polarization
A Mantovani et al.
TRENDS IN IMMUNOLOGY (2004)
Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis
JR White et al.
GENOMICS (2004)
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
H Hurwitz et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells
Y Makino et al.
JOURNAL OF IMMUNOLOGY (2003)
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis
M De Bandt et al.
JOURNAL OF IMMUNOLOGY (2003)
Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis
AO Afuwape et al.
GENE THERAPY (2003)
Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis
DH Solomon et al.
CIRCULATION (2003)
HIF-1α is essential for myeloid cell-mediated inflammation
T Cramer et al.
CELL (2003)
Hypoxia inducible factor 1α and 2α overexpression in inflammatory bowel disease
A Giatromanolaki et al.
JOURNAL OF CLINICAL PATHOLOGY (2003)
Upregulated hypoxia inducible factor-1 alpha and -2 alpha pathway in rheumatoid arthritis and osteoarthritis
A Giatromanolaki et al.
ARTHRITIS RESEARCH & THERAPY (2003)
Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis
KI Mecklenburgh et al.
BLOOD (2002)
Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts
C Hitchon et al.
ARTHRITIS AND RHEUMATISM (2002)
Expression of HIF-Iα by human macrophages:: implications for the use of macrophages in hypoxia-regulated cancer gene therapy
B Burke et al.
JOURNAL OF PATHOLOGY (2002)
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
CC Caldwell et al.
JOURNAL OF IMMUNOLOGY (2001)
Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice
H Sone et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts
RD Thornton et al.
BIOCHEMICAL JOURNAL (2000)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
KL Talks et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis
J Lu et al.
JOURNAL OF IMMUNOLOGY (2000)