期刊
NATURE REVIEWS RHEUMATOLOGY
卷 6, 期 10, 页码 572-577出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrrheum.2010.143
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资金
- Arthritis Research UK
Rheumatoid arthritis (RA) is characterized by chronic inflammation leading to joint destruction. Regulatory T (T-REG) cells are potent suppressors of autoimmunity, but are not capable of controlling every aspect of the inflammatory reaction. We have found that T-REG-cell function is abnormal in patients with RA, and that a distinct population of T-REG cells with potent suppressive properties is induced after therapy with inhibitors of tumor necrosis factor. In this Review, we discuss the mutual interactions between the opposing forces of T-REG cells and inflammation in the context of RA. Therapeutic approaches that enhance T-REG-cell function whilst controlling inflammation are likely to be the most effective strategies for restoring immune tolerance in patients with this disease.
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