期刊
NATURE REVIEWS NEUROSCIENCE
卷 19, 期 9, 页码 535-551出版社
NATURE PORTFOLIO
DOI: 10.1038/s41583-018-0039-7
关键词
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资金
- US National Institutes of Health (NIH) [R01MH108665, R01MH094757, R21MH112956]
- NIH [F32MH109274]
- Frazier Foundation Grant for Mood and Anxiety Research
- US National Institute of Mental Health
- Howard Hughes Medical Institute
- National Alliance for Research on Schizophrenia Depression
- Burroughs Wellcome Foundation
Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly consequence of exposure to severe psychological trauma. Although effective treatments exist for some individuals, they are limited. New approaches to intervention, treatment and prevention are therefore much needed. In the past few years, the field has rapidly developed a greater understanding of the dysfunctional brain circuits underlying PTSD, a shift in understanding that has been made possible by technological revolutions that have allowed the observation and perturbation of the macrocircuits and microcircuits thought to underlie PTSD-related symptoms. These advances have allowed us to gain a more translational knowledge of PTSD, have provided further insights into the mechanisms of risk and resilience and offer promising avenues for therapeutic discovery.
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