期刊
NATURE REVIEWS NEUROSCIENCE
卷 15, 期 4, 页码 233-249出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3689
关键词
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资金
- FONDECYT [1140549]
- Millennium Institute [P09-015-F]
- Ring Initiative [ACT1109]
- FONDEF [D11I1007]
- CONICYT [USA2013-0003, ECOS-CONICYTC13S02]
- ALS Therapy Alliance
- Muscular Dystrophy Association
- Alzheimer's Disease Association
- CNRS (ANR LipidinRetina and Ire1-PD)
- Fondation de France
- Fondation ARC pour la recherche sur le cancer
The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well characterized in non-neuronal cells, a proliferation of papers over the past few years has revealed a key role for the UPR in normal neuronal function and as an important driver of neurodegenerative diseases. A complex scenario is emerging in which distinct UPR signalling modules have specific and even opposite effects on neurodegeneration depending on the disease context. Here, we provide an overview of the most recent findings addressing the biological relevance of ER stress in the nervous system.
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