期刊
NATURE REVIEWS NEUROSCIENCE
卷 15, 期 10, 页码 655-669出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3785
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资金
- Spanish Ministry of Science and Innovation [SAF2011-27766]
- Marie Curie Career Integration Grant [FP7-PEOPLE-2011-CIG 304248]
- Knell Foundation
- Norwegian Research Council
- Allen Institute for Brain Science
The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) hippocampus mediates anxiety-related behaviours. However, this 'dichotomy view' may need revision. Gene expression studies demonstrate multiple functional domains along the hippocampal long axis, which often exhibit sharply demarcated borders. By contrast, anatomical studies and electrophysiological recordings in rodents suggest that the long axis is organized along a gradient. Together, these observations suggest a model in which functional long-axis gradients are superimposed on discrete functional domains. This model provides a potential framework to explain and test the multiple functions ascribed to the hippocampus.
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