期刊
NATURE REVIEWS NEUROSCIENCE
卷 15, 期 10, 页码 637-654出版社
NATURE PORTFOLIO
DOI: 10.1038/nrn3819
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资金
- European Research Council Advanced Grant
- Sigrid Juselius Foundation
- Jane and Aatos Erkko Foundation
- US National Institutes of Health [NS065926, GM 102575, NS36296]
- Academy of Finland (AoF), AoF (ERA-Net NEURON II CIPRESS)
Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades, research on ion transporters is in its infancy. In recent years, it has become evident that one family of ion transporters, cation-chloride cotransporters (CCCs), and in particular K+-Cl- cotransporter 2 (KCC2), have seminal roles in shaping GABAergic signalling and neuronal connectivity. Studying the functions of these transporters may lead to major paradigm shifts in our understanding of the mechanisms underlying brain development and plasticity in health and disease.
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