期刊
NATURE REVIEWS NEUROSCIENCE
卷 15, 期 3, 页码 181-192出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3677
关键词
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资金
- Wellcome trust [074385, 087736]
- European Research Council (GABAcellsAndMemory) [250047]
- Deutsche Forschungsgemeinschaft [SFB 636/A4]
- Max Planck Society
- European Research Council (ERC) [250047] Funding Source: European Research Council (ERC)
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.
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