期刊
NATURE REVIEWS NEUROSCIENCE
卷 15, 期 5, 页码 327-335出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3725
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资金
- ERC [340368]
- Swiss National Science Foundation [31003A 140999]
- NCCR Synapsy
- NCCR Transcure
- Swiss National Science Foundation (SNF) [31003A_140999] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [340368] Funding Source: European Research Council (ERC)
Astrocyte Ca2+ signalling has been proposed to link neuronal information in different spatial-temporal dimensions to achieve a higher level of brain integration. However, some discrepancies in the results of recent studies challenge this view and highlight key insufficiencies in our current understanding. In parallel, new experimental approaches that enable the study of astrocyte physiology at higher spatial-temporal resolution in intact brain preparations are beginning to reveal an unexpected level of compartmentalization and sophistication in astrocytic Ca2+ dynamics. This newly revealed complexity needs to be attentively considered in order to understand how astrocytes may contribute to brain information processing.
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