期刊
NATURE REVIEWS NEUROSCIENCE
卷 15, 期 4, 页码 209-216出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3710
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资金
- Wellcome Trust [RG50995]
- Roman Herzog Postdoctoral Fellowship of the charitable Hertie Foundation (Frankfurt, Germany)
- MRC [MR/L010593/1] Funding Source: UKRI
- Medical Research Council [MR/L010593/1] Funding Source: researchfish
Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well as synapses and the processes of live neurons. However, we and others have recently shown that microglia can also execute neuronal death by phagocytosing stressed-but-viable neurons - a process that we have termed phagoptosis. In this Progress article, we discuss evidence suggesting that phagoptosis may contribute to neuronal loss during brain development, inflammation, ischaemia and neurodegeneration.
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