期刊
NATURE REVIEWS NEUROSCIENCE
卷 15, 期 1, 页码 19-31出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3641
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资金
- US National Institutes of Health [P01 NS47399 P01 NS 047399, GM087369, NS054791]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM087369] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS047399, R01NS014624, R01NS054791] Funding Source: NIH RePORTER
Chemicals that are used experimentally to evoke itch elicit activity in diverse subpopulations of cutaneous pruriceptive neurons, all of which also respond to painful stimuli. However, itch is distinct from pain: it evokes different behaviours, such as scratching, and originates from the skin or certain mucosae but not from muscle, joints or viscera. New insights regarding the neurons that mediate the sensation of itch have been gained from experiments in which gene expression has been manipulated in different types of pruriceptive neurons as well as from comparisons between psychophysical measurements of itch and the neuronal discharges and other properties of peripheral and central pruriceptive neurons.
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