期刊
NATURE REVIEWS NEUROSCIENCE
卷 14, 期 11, 页码 755-769出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3586
关键词
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资金
- US National Institutes of Health (NIH) [NS045523, NS075672, NS041590, NS049553]
- Harvard Stem Cell Institute
- Massachusetts Spinal Cord Research Program
- US NIH individual predoctoral National Research Service Award [NS064730]
- DEARS Foundation
- Harvard Medical Scientist Training Program
- USNIH individual predoctoral National Research Service Award [NS080343]
The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation. In recent years, several key controls over the specification and differentiation of neocortical projection neurons have been identified. This work provides substantial insight into the 'molecular logic' underlying cortical development and increasingly supports a model in which individual progenitor-stage and postmitotic regulators are embedded within highly interconnected networks that gate sequential developmental decisions. Here, we provide an integrative account of the molecular controls that direct the progressive development and delineation of subtype and area identity of neocortical projection neurons.
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