期刊
NATURE REVIEWS NEUROSCIENCE
卷 14, 期 3, 页码 202-216出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3444
关键词
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资金
- Spanish Ministry of Economy and Competitiveness [TIN2010-20900-C04-04, SAF2009-09394]
- Cajal Blue Brain Project, Spanish partner of the Blue Brain Project initiative from EPFL
- National Institutes of Health [R01-39600]
- Grants-in-Aid for Scientific Research [24120718, 21240030] Funding Source: KAKEN
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxononnical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.
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