期刊
NATURE REVIEWS NEUROSCIENCE
卷 14, 期 12, 页码 839-850出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3642
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资金
- Swedish Research Council [K2013-62X-12600-16-4]
- Swedish State Support for Clinical Research [ALFGBG-136991]
- Swedish Brain Foundation [FO2011-003]
Synapses are constantly generated at a high rate in the developing, prepubescent brain. Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Most of these 'AMPA-silent' synapses are eliminated during the developmental period, but some are specifically selected for AMPA unsilencing by correlated pre- and postsynaptic activity as the first step in a process that leads to stabilization of the synapse. Premature, or delayed, unsilencing of AMPA-silent synapses has been implicated in neurodevelopmental disorders, and abnormal generation of AMPA-silent synapses is associated with brain trauma, addiction and neurodegenerative disorders, further highlighting the importance of AMPA-silent synapses in brain pathology.
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