期刊
NATURE REVIEWS NEUROSCIENCE
卷 13, 期 3, 页码 169-182出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3192
关键词
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资金
- Ellison Foundation
- US National Institutes of Health [R01 DA027807]
- Marine Biological Laboratory
Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII subsequently translocates to the synapse, where it binds to NMDA-type glutamate receptors and produces potentiation by phosphorylating principal and auxiliary subunits of AMPA-type glutamate receptors. These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse.
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