期刊
NATURE REVIEWS NEUROSCIENCE
卷 13, 期 6, 页码 365-379出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3170
关键词
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资金
- Gatsby Charitable Trust (London, UK)
- Howard Hughes Medical Institute (Maryland, USA) [43667]
- Mathers Foundation (New York, USA)
- National Institute of Neurological Diseases and Stroke (Maryland, USA) [1R21NS063210, 1R01NS075252, 1R01NS077601]
Pioneering studies in the middle of the twentieth century revealed substantial diversity among mammalian chemical synapses and led to a widely accepted classification of synapse type on the basis of neurotransmitter molecule identity. Subsequently, powerful new physiological, genetic and structural methods have enabled the discovery of much deeper functional and molecular diversity within each traditional neurotransmitter type. Today, this deep diversity continues to pose both daunting challenges and exciting new opportunities for neuroscience. Our growing understanding of deep synapse diversity may transform how we think about and study neural circuit development, structure and function.
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