期刊
NATURE REVIEWS NEUROSCIENCE
卷 13, 期 7, 页码 465-477出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3257
关键词
-
资金
- US National Institutes of Health (NIMH) (Maryland, USA)
- National Alliance for Research in Schizophrenia and Affective Disorders
- Hereditary Disease Foundation/High Q
- CHDI, Inc.
- US National Institutes of Health (NINDS) (Maryland, USA)
- US National Institutes of Health (NICHD) (Maryland, USA)
The essential amino acid tryptophan is not only a precursor of serotonin but is also degraded to several other neuroactive compounds, including kynurenic acid, 3-hydroxykynurenine and quinolinic acid. The synthesis of these metabolites is regulated by an enzymatic cascade, known as the kynurenine pathway, that is tightly controlled by the immune system. Dysregulation of this pathway, resulting in hyper- or hypofunction of active metabolites, is associated with neurodegenerative and other neurological disorders, as well as with psychiatric diseases such as depression and schizophrenia. With recently developed pharmacological agents, it is now possible to restore metabolic equilibrium and envisage novel therapeutic interventions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据