期刊
NATURE REVIEWS NEUROSCIENCE
卷 13, 期 4, 页码 251-266出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3171
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资金
- US National Institute of Mental Health (NIMH) [1F32MH088010-01]
- Picower Institute of Learning and Memory
- Picower Institute Innovation Funds (PIIF)
- NIMH
- US National Institute on Drug Abuse
- US National Institute of Neurological Disorders and Stroke
- Howard Hughes Medical Institute
- Defense Advanced Research Projects Agency Reorganization
- Keck Foundation
- Wiegers Family Gift Fund
- Gatsby Charitable Foundation
Optogenetic tools have provided a new way to establish causal relationships between brain activity and behaviour in health and disease. Although no animal model captures human disease precisely, behaviours that recapitulate disease symptoms may be elicited and modulated by optogenetic methods, including behaviours that are relevant to anxiety, fear, depression, addiction, autism and parkinsonism. The rapid proliferation of optogenetic reagents together with the swift advancement of strategies for implementation has created new opportunities for causal and precise dissection of the circuits underlying brain diseases in animal models.
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