期刊
NATURE REVIEWS NEUROSCIENCE
卷 12, 期 2, 页码 73-87出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2977
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资金
- Flanders Institute for Biotechnology (VIB)
- Fonds voor Wetenschappelijk onderzoek (FWO)
- Stichting Alzheimer Onderzoek-Fondation pour la recherche de la maladie d'Alzheimer (SAO-FRMA)
- Federal Office for Scientific Affairs, Belgium [IUAP P6/43/]
- Catholic University of Leuven (KUL)
- Flemish Government
- Memosad of European Union [FZ-2007-200611]
- Arthur Bax and Anna Vanluffelen Chair for Alzheimer's Disease
G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly influence the amyloid cascade through modulation of the alpha-, beta- and gamma-secretases, proteolysis of the amyloid precursor protein (APP), and regulation of amyloid-beta degradation. Additionally, amyloid-beta has been shown to perturb GPCR function. Emerging insights into the mechanistic link between GPCRs and AD highlight the potential of this class of receptors as a therapeutic target for AD.
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