期刊
NATURE REVIEWS NEUROSCIENCE
卷 11, 期 12, 页码 791-797出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2935
关键词
-
资金
- National Institutes of Health (NIH), National Institute on Aging
Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene-leucine-rich repeat kinase 2 (LRRK2) - affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically a-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.
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